How to choose the right size STX Cell IV lacrosse gloves. What are the key features of these gloves. How do they compare to other lacrosse glove options. What is STX’s warranty policy for these gloves.
Understanding Lacrosse Glove Sizing
Proper glove sizing is crucial for optimal performance and comfort in lacrosse. To find your ideal glove size:
- Measure from the tip of your middle finger to where your wrist meets your palm
- Compare this measurement to the sizing chart provided by STX
- Choose a size that fits snugly with fingertips touching the glove’s edge
Avoiding gloves that are too loose is important, as this can make stick control difficult, especially for newer players. It’s best to select gloves that fit well now rather than sizing up to “grow into”.
STX Lacrosse Glove Sizing Chart
Size | Hand Length (inches) | Approx. Weight (lbs) |
---|---|---|
XX-Small (6″) | > 6″ | Under 50 |
X-Small (8″) | 6″ | 50 – 60 |
Small (10″) | 6.5″ | 70 – 90 |
Medium (12″) | 7″ | 90 – 120 |
Large (13″) | 7.5″ | 130 – 190 |
X-Large (14″) | 7.75″ + | 190 + |
This chart serves as a general guideline. For personalized sizing assistance, contacting STX customer service is recommended.
Key Features of STX Cell IV Lacrosse Gloves
The STX Cell IV lacrosse gloves offer several notable features that make them a popular choice among players:
- Advanced protection: Designed to absorb impacts and shield hands during play
- Enhanced mobility: Flexible construction allows for natural hand movements
- Moisture-wicking material: Helps keep hands dry and comfortable during intense games
- Durable construction: Built to withstand the rigors of regular lacrosse play
- Stylish design: Available in various color options, including white
Do these gloves provide adequate ventilation? Yes, the STX Cell IV gloves incorporate ventilation features to promote airflow and reduce hand sweat during play.
Comparing STX Cell IV to Other Lacrosse Gloves
When evaluating the STX Cell IV gloves against other options on the market, several factors come into play:
- Protection level: The Cell IV offers robust protection comparable to high-end gloves
- Comfort: Many players report excellent comfort and fit with these gloves
- Price point: Generally considered a mid-range option, balancing quality and affordability
- Brand reputation: STX is a well-established and respected brand in lacrosse equipment
Are STX Cell IV gloves suitable for all skill levels? Indeed, these gloves are designed to cater to players across various skill levels, from beginners to advanced players.
STX Warranty and Customer Support
STX offers a “Limited Warranty” on their protective gear and gloves. Key points of this warranty include:
- 30-day coverage from the date of purchase
- Replacement for unusable or broken products due to poor workmanship or material failure
- Coverage applies to normal playing conditions only
To initiate a warranty claim, customers should email STX Customer Service at [email protected] for replacement instructions.
Does the warranty cover wear and tear? No, the STX warranty is specifically for defects in workmanship or materials, not normal wear and tear from regular use.
Caring for Your STX Cell IV Lacrosse Gloves
Proper maintenance can extend the life of your lacrosse gloves and ensure optimal performance. Here are some tips for caring for your STX Cell IV gloves:
- Air out gloves after each use to prevent odor buildup
- Clean with a damp cloth and mild soap as needed
- Avoid machine washing or drying, which can damage the gloves
- Store in a cool, dry place when not in use
- Regularly inspect for signs of wear and tear
Can you use disinfectant sprays on these gloves? While it’s possible to use disinfectant sprays, it’s best to test on a small, inconspicuous area first to ensure it doesn’t damage the material.
Enhancing Performance with STX Cell IV Gloves
The right lacrosse gloves can significantly impact a player’s performance on the field. The STX Cell IV gloves offer several benefits:
- Improved stick control due to their snug fit and flexible design
- Increased confidence in physical play thanks to robust protection
- Better endurance in long games or practices with their moisture-wicking properties
- Enhanced grip on the lacrosse stick, potentially improving passing and shooting accuracy
Do these gloves require a break-in period? While the STX Cell IV gloves are designed for comfort right out of the box, some players may experience a short break-in period as the gloves conform to their hand shape.
STX Cell IV Gloves for Different Lacrosse Positions
Different positions in lacrosse may benefit from specific glove features. The STX Cell IV gloves are versatile enough to suit various positions:
- Attackmen: Appreciate the balance of protection and mobility for quick stick handling
- Midfielders: Benefit from the gloves’ lightweight design for fast transitions
- Defensemen: Value the robust protection during physical encounters
- Goalies: May prefer specialized goalie gloves, but can use Cell IV gloves for practice
Are there position-specific versions of the STX Cell IV gloves? While the standard Cell IV gloves are suitable for all field positions, STX does offer specialized goalie gloves in their product lineup.
Customization Options for STX Cell IV Lacrosse Gloves
Personalizing lacrosse equipment can help players express their style and stand out on the field. While the STX Cell IV gloves come in standard color options, there are ways to customize them:
- Team color coordination: Choose glove colors that match your team’s uniform
- Personal embroidery: Some retailers offer embroidery services for adding names or numbers
- Decorative tape: Apply colored tape to certain areas for a unique look
- Aftermarket modifications: Some players add grip enhancers or padding for personalized comfort
Does customizing the gloves void the warranty? Minor cosmetic customizations typically don’t void the warranty, but significant alterations or modifications may affect warranty coverage. It’s best to check with STX customer service for specific cases.
The Impact of Glove Choice on Lacrosse Performance
Selecting the right lacrosse gloves, such as the STX Cell IV, can have a significant impact on a player’s performance and enjoyment of the game. Here’s how:
- Protection: Proper protection instills confidence, allowing players to focus on their game without fear of injury.
- Comfort: Comfortable gloves reduce distraction and fatigue during long practices or games.
- Stick control: Well-fitting gloves enhance a player’s ability to manipulate the lacrosse stick accurately.
- Weather adaptation: Quality gloves like the Cell IV help players perform consistently in various weather conditions.
Can the right gloves really improve a player’s game? While gloves alone won’t make a player great, high-quality, well-fitting gloves like the STX Cell IV can certainly contribute to improved performance by enhancing comfort, protection, and stick control.
STX Cell IV Gloves in Competitive Play
The STX Cell IV gloves are widely used in competitive lacrosse at various levels. Their popularity in competitive settings stems from several factors:
- Compliance with regulation standards for most leagues and tournaments
- Durability to withstand the intensity of competitive play
- Performance features that cater to the demands of high-level lacrosse
- Brand recognition and trust among coaches and players
Are these gloves approved for all levels of play? The STX Cell IV gloves meet the requirements for most lacrosse leagues and levels, from youth to collegiate play. However, it’s always best to check specific league regulations to ensure compliance.
Comparing STX Cell IV to Previous Models
The STX Cell IV gloves represent an evolution in STX’s glove design. When compared to previous models, several improvements are notable:
- Enhanced protection in key impact areas
- Improved ventilation for better temperature regulation
- More flexible cuff design for increased wrist mobility
- Updated aesthetics with a modern, sleek look
Have there been any significant technological advancements in the Cell IV model? Yes, the Cell IV incorporates advancements in materials and design, particularly in the areas of impact protection and flexibility, compared to its predecessors.
The Future of Lacrosse Glove Technology
As lacrosse equipment continues to evolve, we can expect to see further advancements in glove technology. Some potential future developments might include:
- Smart gloves with integrated sensors for performance tracking
- Advanced materials offering even better protection-to-weight ratios
- Customizable fit options using 3D printing technology
- Enhanced sustainability features, such as eco-friendly materials and production methods
How might future technologies impact glove design and performance? Emerging technologies could lead to gloves that not only offer superior protection and comfort but also provide players with real-time performance data and unprecedented levels of customization.
Making the Most of Your STX Cell IV Gloves
To maximize the benefits of your STX Cell IV lacrosse gloves, consider the following tips:
- Break them in properly by wearing them during practice sessions before competitive play
- Regularly clean and maintain the gloves to preserve their performance and longevity
- Use them consistently to develop muscle memory and familiarity with their feel
- Pair them with appropriate stick tape to optimize grip and control
- Replace them when they show signs of significant wear to ensure continued protection
How often should lacrosse gloves be replaced? The lifespan of lacrosse gloves varies depending on usage frequency and intensity. However, most players typically replace their gloves every 1-2 seasons to ensure optimal protection and performance.
STX Cell 4 Lacrosse Gloves
Lacrosse Glove Sizing Guide
Measure the length between the tip of the middle finger and the point where the wrist meets the palm. This is the distance that the glove palm will cover. This distance will approximately correspond with the size chart provided bellow.
When purchasing gloves, you want to make sure that the gloves fit snuggly and the fingertips are touching the edge of glove. Loose fitting gloves make it difficult to control the stick and can be frustrating to deal with (especially for newer players). Try to purchase the best fitting gloves for right now and avoid buying the next size up to “grow into”.
If you are looking for a more in-depth look at selecting lacrosse gloves sizes, please visit Lacrosse Glove Sizing Guide or contact our customer support team for personalized guidance.
Lacrosse Glove Sizing Chart | |||
Size | Hand Length (inches) | ≈ Weight (lbs) | |
---|---|---|---|
XX-Small – 6″ | > 6″ | Under 50 | |
X-Small – 8″ | 6″ | 50 – 60 | |
Small – 10″ | 6.5″ | 70 – 90 | |
Medium – 12″ | 7″ | 90 – 120 | |
Large – 13″ | 7.5″ | 130 – 190 | |
X-Large 14″ | 7.75″ + | 190 + | |
This sizing chart is provided as a general guideline. Please contact customer service for additional sizing guidance. |
STX protective and gloves are covered by a “Limited Warranty”. STX will replace unusable or broken products (or provide a replacement with equal value) that break or become unusable under normal playing conditions due to poor workmanship and/or material failure within thirty (30) days from the date of purchase.
Please email STX Customer Service at [email protected] for replacement instructions.
For more information please visit http://www.stx.com/legal/warranty.
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Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells
Cellular structure and function of the blood-brain barrier
At the interface of the circulatory and central nervous system (CNS), the BBB acts as a key regulatory site for the control of the homoeostatic CNS microenvironment, which is essential for the proper functioning and protection of the nervous system.The site of the BBB is the endothelial cell lining the lumen of the blood vessel. In the capillaries of the brain, endothelial cells form a complex of intercellular tight junctions and highly polarized expression patterns of specific influx and measurable carriers to provide very specific molecular transport between the blood and the brain 1 . Structural components are rigid junction complexes of proteins from the family occludin and claudin, zonula occludens (ZO) proteins, cingulin and bound connective adhesion molecules (jams).Claudine 5 is especially important in paracellular connective restrictions. The induction and maintenance of this characteristic BBB endothelial phenotype involve dynamic interactions with surrounding cells including pericytes, astrocytes, neurons, and basement membranes, which together with brain endothelial cells form the neurovascular unit (NVU) 2 , 3 . The mechanisms involved in these interactions are not yet fully understood, but include the exchange of chemical signals between cells, which allows modulation of BBB permeability in the short term and causes long term BBB features 4 .Astrocytes are especially known to contribute the phenotype of brain endothelial cells and are a source of regulation of factors such as glial neurotrophic factor (intracellular camp) 5 90 380, major fibroblastic growth factor 6 90 380, hydrocortisone 7 90 380 and transformation growth factor β (TGF-β) 8 . However, the effect of TGF-β has been discussed 9 .
Natural in Vitro BBB
The vivo studies continue to provide valuable information on the biology of the BBB.However, cell culture models can provide additional insights and provide useful tools for understanding the detailed molecular and functional aspects of BBB in health and disease. Although complex interactions between cell types and BBB constituents are difficult to fully achieve in in vitro models, there has been since the first purification of brain endothelial cells and their application in monocultures 10 , 11 , 12 , extensive development of purification procedures and growth conditions of the BBB cell culture model, leading to greater similarity between the barrier in vivo .Often used in vitro BBB models are based on primary cells of rodent, porcine and bovine origin and on immortalized cell lines. Each model has its own advantages and disadvantages. For comparison and model selection validation markers such as BBB expression enzymes, transporters, receptors, and structural proteins are used to generate reviews of the current established model 1 .
Purpose of the protocol
One important feature of the BBB barrier is tightness and high TEP, but the large number of models available also do not reflect levels in vivo .Incorporating development and optimization input from multiple laboratories, the goal of this protocol is to present a method for generating high TEEP in a vitro BBB model based on primary pBECs in MCs with or without ACM, or in NCCs with initial astrocytes of rat or porcine origin. The applied procedures and model creation include efforts to eliminate contaminating cells and to improve the differentiation of pBECs into the BBB phenotype. This work has resulted in the creation of reliable, high quality TEP models with low paracellular permeability and good functional expression of key tight connective proteins, transporters and receptors.However, as astrocytes are a contributing factor to the phenotype of brain endothelial cells, three different culture conditions represent three different phenotypes of brain endothelial cells. The NCC model is specifically useful for investigating some of the specialized mechanisms involved in drugs, transport studies, and intracellular humans, as well as for investigating cell interactions where maximizing the expression of BBB functions is beneficial.
Origins and history of the protocol
The pBEC model described here is mainly based on the porcine model developed in the laboratory “Eisai” (London) by Dr. Louise Morgan and colleagues, whichis, based on the previously successful brain endothelial cell model 13 .The original cell preparation method was a two-stage filtration using nylon mesh to catch microvessels, followed by a subculturing step to improve cleanliness. In the earlier development of the method, optimal BBB phenotype and barrier tightness were achieved by growth in supplement media including ACM. In the laboratory of prof. n. Rothwell to Manchester UK 14 , 15 90 380 RUB Skinner made further changes to the method. This technique was adopted at the Abbott Laboratory, KCL London, where Patabendige made it much easier to prepare by avoiding the use of astrocytes or ACM and eliminating harmful cells such as pericytes with puromycin.Papers first confirmed that the MC model retained several important features of in vivo BBB, including efficient tight junctions, membrane transport systems and receptor mediated Transcytosis 16 90 380 , 17 90 380 , 18 90 380 , 90 380 19 , 20 . later S. Yusuf tested exocytosis again Co-culture and it improved significantly TEP, so this is the preferred option, currently used in the Abbott laboratory 21 .The model was successfully transferred to the M. Nielsen laboratory in Aarhus, where further changes were introduced (this protocol), including the simplification of the gray matter of extraction, using only one mesh filtration step and one filter step covering a combination of collagen and fibronectin. The applied procedure for the isolation of porcine astrocytes (this protocol) was based on the protocols developed by the Moos laboratory in Aalborg described by Thomsen et al 22 . TEEP and other properties of the model created in London and Aarhus are similar, which gives confidence that the model is easily transferred between laboratories and responds well to careful observation and rationalization of the method of action.Indeed S. Yusuf has now created an MC model for tropical countries (Malaysia) 23 , suggesting additional adjustments for local conditions and tissue sources.
Advantages over alternative methods and
models are currently created
Compared to endothelial cells of the brain of bovine and rodent origin, pBECs provide the advantage of a lower loss rate of in vivo of the BBB phenotype after isolation 24 .In addition, pBECs are able to form relatively rigid endothelial barriers, even when grown at 16 MC (800 Ω cm 2 ) compared to frequently reported levels for monolayer cell lines such as bEND.5 and bEND.3 (50 Ω cm 2 ) 25 , 26 , 27 , cEND (300-800 Ω cm 2 ) 28 , 29 , 30 90 500 380 and cereb Ω cm 2 ) 29 , , 31 32 and primary brain endothelial cells of the mouse (100-300 Ω cm 2 ) cla> SS = “external”> 33 , 34 , , 35 36 and rat (100-300 Ω cm 2 ) 37 , 38 .However, TEEP has shown dependence on cleaning and culture procedures. In most cases, the addition of ACM or co-culture with astrocytes shows differentiation of effects on endothelial cells and an increase in the tightness of the endothelial layer 1 . However, with efforts to optimize culture conditions, only model-based beef showed TEP values comparable to pork-based models (average 800 Ω cm 2 90 380 in MC, up to 2500 Ω cm 2 90 380 exocytosis co-culture) 13 , 39 , 40 , , 41 42 , , 43 44 , Both models based on primary brain endothelial cells have shown large variations, both between and in the laboratory 14 , 45 , 46 , 47 , 48 , reproducibility can be a problem. In the pBEC model, the participating laboratories reported here have achieved very similar TEP and paracellular permeability values with low variability, both within and between laboratories. Therefore, it should be possible for other laboratories to establish a robust model with low variability using the method presented here.In addition to the formation of a rigid endothelial layer, models with pBECs have previously been validated by the expression of tight junction proteins, functional BBB transporters, receptors and enzymes and demonstrated suitability for a number of studies 15 90 380 , 16 , 17 , 19 , 20 , 22 , 49 , 50 , 51 , 52 , , , 55 , 56 , 57 , 58 , 59 .In addition, unpublished transcript data on culture cooperation of pBECs shows the expected profile of BBB transporters and receptors (unpublished results, Nielsen et al. ).
BBB porcine oriented model has another advantage as the genome, anatomy, physiology, and disease progression of pigs reflect human biology more than other established models 60 , which are favorable opportunities for the pharmaceutical industry.As pig brains are a common by-product of the meat industry, they represent an easily accessible source of brain endothelial cells, minimize the number of animals for experimentation, and provide a high purification yield from a single pig brain. Although purification and culturing of primary cells is somewhat laborious and requires knowledge for standardization in model creation, primary elements generate the most robust BBB models. Immortalized cell lines cannot replace, as important properties such as barrier tightness, transporter expression profiles and microenvironment regulation do not reflect the experimental findings in vivo 61 , 62 . in vitro models provide the advantage of high-resolution cell imaging, the ability to visualize intracellular processes, allowing a close approach to the sample or observed cell, using targets with magnification and better optical quality 63 . This is not the case for the use of two photon microscopy in live animals. In addition, the in vitro model provides the ability to transfect cells, allowing visualization of tagged proteins and the investigation of their illegal trade.
Application of model
BBB function is not fixed and can be dynamically modulated in physiology and pathology. In many neurological diseases, including neurodegenerative inflammatory and infectious diseases, disorders and increased permeability of the BBB is observed 64 , 65 , 66 , 67 . In order to reduce and prevent disease progression and subsequent damage, the identification and characterization of the molecular mechanisms underlying BBB modulation are of great importance.In this context, the robust in vitro model is in high demand in the pharmaceutical industry and furthermore play an important role in BBB prediction of drug permeability in the CNS. Any model in vitro serving as a permeability screen should display restrictive paracellular pathways, physiologically realistic cell architecture, and functional expression transporter mechanisms 68 . Demonstrated in previous studies 16 , 17 , 57 and paracellular permeability and expression of AJ and TJ proteins here, the presented model meets all of these criteria and is suitable for the range of BBB studies in both normal physiology and pathology.The advantages of the presented purification and culture method include the combination of simplicity and reproducibility and the ability to incorporate astrocytic influences with the resulting robust and high TEP in vitro BBB model. For this purpose, astrocytes from pork and rat origin have been shown to increase the BBB phenotype of pBECs in a similar manner 22 .
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