Com di. Decoding DI: Comprehensive Guide to Digital Interfaces and Technology Acronyms

What is the meaning of DI in various fields. How does DI impact technology, government, and science. What are the most common interpretations of DI across industries.

The Multifaceted Meanings of DI: From Tech to Military

DI is an acronym that carries diverse meanings across multiple sectors. Its interpretation varies significantly depending on the context in which it’s used. Let’s explore some of the most prevalent definitions and their implications in different fields.

Technology Sector Interpretations

In the realm of technology, DI often stands for:

• Digital Input
• Digital Interface
• Digital Intermediate
• Digital Imagery

Digital Input refers to the process of converting analog signals into digital format, enabling computers to process and store information efficiently. How does this impact our daily lives? Digital inputs are crucial in various devices, from smartphones to industrial sensors, allowing for precise data collection and analysis.

Digital Interface, on the other hand, pertains to the connection between digital devices or between a digital device and a user. This concept is fundamental in user experience design and system integration. Can you imagine using a computer without a keyboard or mouse? These are examples of digital interfaces that facilitate human-computer interaction.

Government and Military Applications

In government and military contexts, DI can represent:

• Defense Information
• Directorate of Intelligence
• Dismounted Infantry
• Defense Investment

Defense Information is a broad term encompassing various aspects of military intelligence and data management. How does this influence national security? By effectively managing and analyzing defense information, countries can make informed decisions about their military strategies and resource allocation.

The Directorate of Intelligence, often associated with intelligence agencies, is responsible for collecting and analyzing information crucial to national security. This division plays a pivotal role in providing policymakers with the insights needed to address potential threats and make strategic decisions.

DI in Science and Medicine: Advancing Research and Patient Care

The scientific and medical communities utilize DI in several ways:

• Diagnostic Imaging
• Drug Interaction
• Diabetes Insipidus
• Disability Index

Diagnostic Imaging is a cornerstone of modern medicine, encompassing techniques like X-rays, MRIs, and CT scans. How has this technology revolutionized healthcare? By providing detailed internal images of the body, diagnostic imaging enables physicians to identify and treat conditions with unprecedented accuracy and speed.

Drug Interaction is a critical concept in pharmacology, referring to the effects that occur when multiple drugs are taken simultaneously. Understanding these interactions is crucial for patient safety and effective treatment. Are you aware of potential drug interactions in your current medications? It’s always advisable to consult with a healthcare professional or pharmacist to ensure the safe combination of prescribed drugs.

Business and Organizational Interpretations of DI

In the business world, DI can stand for:

• Disability Insurance
• Dependency Injection
• Document Imaging
• Data Interoperability

Disability Insurance provides financial protection for individuals who become unable to work due to illness or injury. How does this safety net benefit both employees and employers? By offering income security during challenging times, disability insurance helps maintain workforce stability and supports employee well-being.

Dependency Injection is a software design pattern that promotes loose coupling between components, enhancing modularity and testability. This technique is widely used in modern software development to create more maintainable and scalable applications. Have you ever worked on a project that utilized dependency injection? If so, you’ve likely experienced the benefits of more flexible and easier-to-test code.

DI in Education: Fostering Inclusive and Effective Learning

Educational professionals often use DI to refer to:

• Differentiated Instruction
• Direct Instruction
• Dual Immersion

Differentiated Instruction is an educational approach that tailors teaching methods to meet the diverse needs of individual students. How does this strategy improve learning outcomes? By recognizing that students have different learning styles, abilities, and interests, teachers can create more engaging and effective lessons that cater to each student’s strengths.

Direct Instruction is a teaching method that emphasizes clearly defined and structured lessons. This approach is particularly effective for teaching foundational skills and concepts. When implemented correctly, direct instruction can provide students with a solid base of knowledge upon which to build more complex understanding.

DI in Engineering and Manufacturing: Innovating Production Processes

In engineering and manufacturing contexts, DI might represent:

• Direct Injection
• Ductile Iron
• Degree of Integration

Direct Injection, in the context of automotive engineering, refers to a fuel delivery system that improves engine efficiency and reduces emissions. How has this technology impacted the automotive industry? By precisely controlling fuel injection, direct injection systems have enabled manufacturers to produce more powerful yet fuel-efficient engines, contributing to both performance improvements and environmental sustainability efforts.

Ductile Iron is a type of cast iron known for its strength and flexibility. This material is widely used in various industries due to its unique properties. Where might you encounter ductile iron in everyday life? It’s commonly used in water and sewer pipes, automotive parts, and heavy machinery components, showcasing its versatility and durability.

DI in Information Technology: Enhancing Data Management and Security

IT professionals often use DI to refer to:

• Data Integration
• Data Integrity
• Document Identifier

Data Integration involves combining data from various sources into a unified view, essential for business intelligence and analytics. How does effective data integration benefit organizations? By providing a comprehensive view of disparate data sources, companies can gain valuable insights, improve decision-making processes, and streamline operations.

Data Integrity ensures the accuracy, consistency, and reliability of data throughout its lifecycle. Why is this concept crucial in the digital age? As businesses increasingly rely on data-driven decision-making, maintaining data integrity is paramount to avoid costly errors and maintain trust in information systems.

DI in Environmental and Energy Sectors: Addressing Global Challenges

In environmental and energy contexts, DI can stand for:

• Deionized (Water)
• Deflation-Inflation (volcanic events)
• Dry Injection (emissions control)

Deionized Water is water that has had its mineral ions removed, making it highly pure. Where is deionized water commonly used? It’s essential in laboratory settings, semiconductor manufacturing, and certain medical applications where even trace impurities could interfere with processes or results.

Deflation-Inflation, in the context of volcanology, refers to the cyclical swelling and contraction of a volcano’s surface. How does monitoring these events contribute to volcanic hazard assessment? By tracking these subtle ground movements, scientists can better predict eruptions and issue timely warnings to nearby populations.

The Future of DI: Emerging Technologies and Applications

As technology continues to evolve, new interpretations and applications of DI are likely to emerge. Some areas to watch include:

• Decentralized Identity in blockchain technology
• Deep Intelligence in artificial intelligence research
• Distributed Infrastructure in cloud computing

Decentralized Identity aims to give individuals more control over their personal data and online identities. How might this technology reshape our digital interactions? By allowing users to manage their own identity credentials without relying on centralized authorities, decentralized identity systems could enhance privacy, reduce fraud, and simplify online verification processes.

Deep Intelligence represents the next frontier in AI research, focusing on creating systems that can understand and reason about complex problems in ways that more closely mimic human cognition. What potential applications could arise from advancements in deep intelligence? From more sophisticated natural language processing to breakthroughs in scientific research, the implications of deep intelligence are far-reaching and could revolutionize numerous industries.

As we’ve explored, the acronym DI carries a multitude of meanings across various fields. Its versatility underscores the importance of context in interpreting acronyms and highlights the interconnected nature of different sectors in our increasingly complex world. Whether you’re a technologist, healthcare professional, educator, or simply a curious individual, understanding the diverse applications of DI can provide valuable insights into the innovations shaping our future.

The evolution of DI in different domains reflects the rapid pace of technological advancement and the growing need for specialized terminology to describe new concepts and processes. As we continue to push the boundaries of science, technology, and human knowledge, it’s likely that we’ll see even more interpretations and applications of DI emerge, further enriching its already diverse lexicon.

In conclusion, the multifaceted nature of DI serves as a reminder of the importance of clear communication and context in our increasingly interconnected world. Whether you’re discussing digital interfaces in technology, diagnostic imaging in healthcare, or differentiated instruction in education, being aware of the various meanings of DI can enhance your understanding and facilitate more effective communication across different fields and disciplines.

What does DI stand for? The Free Dictionary

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hydrogen – No Man’s Sky Wiki

The subject of this article is from the Origins update. The information from this article is up-to-date as of 9 November, 2020.

The subject of this article is from the Origins update.
The information from this article is up-to-date as of 9 November, 2020.

Di-hydrogen is a resource.

Summary[]

Di-hydrogen (H) is a resource and one of the earth elements. It is a main ingredient required to craft fuel for both starships and frigates.

Game description[]

A stable, crystalline form of hydrogen remarkable both for its extreme energy density and its stability at atmospheric pressures.

Common to all worlds, Di-hydrogen is found in the form of large blue crystals. It is a key component of Starship Launch Fuel.

Source[]

Harvesting Di-hydrogen crystals

Di-hydrogen can be found in blue crystal minerals located on nearly every planet. The larger minerals require an Advanced Mining Laser.

Di-hydrogen can be refined using a Refiner with the following ingredients:

Exploit[]

Once the player has at least 40 Di-hydrogen and a Refiner, they can produce their own Di-hydrogen for free.

Crafting method:

1. Use 40 Di-hydrogen to craft a Di-hydrogen Jelly.
2. Refine the Di-hydrogen Jelly to produce 50 Di-hydrogen.
3. Repeat steps 1 and 2, to produce 10 Di-hydrogen per cycle.

Refining method:

1. Refine 30 Di-hydrogen to produce a Di-hydrogen Jelly.
2. Refine the Di-hydrogen Jelly to produce 50 Di-hydrogen .
3. Repeat steps 1 and 2, to produce 20 Di-hydrogen per cycle.

Note: Despite the difference in quantity produced, the crafting method is by far the faster method of producing Di-hydrogen, as the refiner takes 1min (60s) to create 1 Di-hydrogen Jelly, while crafting Di-hydrogen Jelly is instantaneous.

Use[]

Crafting[]

Di-hydrogen is used as an ingredient for crafting the following products:

Refining[]

Di-hydrogen is used as an ingredient for refining the following products using a Refiner:

• Ammonia  —  Nitrogen x1  +  Di-hydrogen x1  →   Ammonia x1  (“Organic Fusion”, 0. 4 sec./unit output)
• Deuterium  —  Di-hydrogen x1  +  Tritium x1  →   Deuterium x1  (“Di-hydrogen Cycling”, 0.6 sec./unit output)
• Di-hydrogen Jelly  —  Di-hydrogen x30  →   Di-hydrogen Jelly x1  (“Condense Di-hydrogen”, 240 sec./unit output)
• Faecium  —  Di-hydrogen x1  +  Carbon x1  →   Faecium x1  (“Assisted Decomposition”, 0.2 sec./unit output)
• Life Support Gel  —  Oxygen x10  +  Condensed Carbon x10  +  Di-hydrogen x10  →   Life Support Gel x1  (“Advanced Oxygen Capture”, 90 sec. /unit output)
• Mordite  —  Di-hydrogen x1  +  Condensed Carbon x1  →   Mordite x1  (“Organic Reassembly”, 0.2 sec./unit output)
• Salt  —  Di-hydrogen x1  +  Oxygen x1  →   Salt x1  (“Rapid Formation/Evaporation”, 0.2 sec./unit output)
• Solanium  —  Di-hydrogen x1  +  Sulphurine x1  →   Solanium x1  (“Sulphur Injection”, 0.4 sec./unit output)
• Starship Launch Fuel  —  Di-hydrogen x10  +  Ferrite Dust x20  +  Sodium Nitrate x5  →   Starship Launch Fuel x1  (“Di-hydrogen Capture”, 90 sec. /unit output)
• Starship Launch Fuel  —  Di-hydrogen x10  +  Magnetised Ferrite x10  +  Sodium Nitrate x5  →   Starship Launch Fuel x1  (“Di-hydrogen Capture”, 90 sec./unit output)
• Starship Launch Fuel  —  Di-hydrogen x10  +  Pure Ferrite x20  +  Sodium x10  →   Starship Launch Fuel x1  (“Di-hydrogen Capture”, 90 sec./unit output)
• Uranium  —  Radon x1  +  Di-hydrogen x1  →   Uranium x1  (“Catalyse Radiation”, 0.4 sec./unit output)

Cooking[]

Di-hydrogen is not used as an ingredient for cooking using a Nutrient Processor.

Additional information[]

• Blue crystals used to be a source of Chrysonite before the NEXT update.

Release history[]

• NEXT – Added as a resource.
• Visions – Hidden changes: The information panel has an additional icon indicating its purpose.

Gallery[]

• Information panel
  (Origins)

• Information panel
  (Beyond)

• Information panel
  (Visions 1.77)

Outdoor Dining in Flatiron District: Il Patio di Eataly

Il Patio di Eataly is open! Enjoy a slice of ‘la dolce vita’ at our piazza-inspired outdoor patio.

At Il Patio di Eataly, you can experience all of the splendor of sitting in an Italian piazza–no passport required. Indulge in aperitivi plates ranging from grande to grandissimo, taste the authenticity of our pizza Napoletana and pasta di Gragnano IGP.  Join us for outdoor dining in the Flatiron district on 5th Avenue!

BOOK YOUR TABLE

HOURS & LOCATION

Sunday – Thursday
11:30am – 9:00pm

Friday and Saturday
11:30am – 9:30pm

MENU

Main Menu
Dessert Menu
Grandi Vini Menu

CELEBRATE ALLA GRANDE 

Italians exclaim “Alla grande!” as a way to rejoice about something, and we want you to enjoy the spring season as Italians would – alla grande! Our experts have crafted a menu full of “great” items (that is, grande and grandissimo – big and extra big!). Find antipasti perfect for sharing with the table like Torre di Frutti di Mare, a tower of fresh oysters, poached shrimp, variety of crudo, calamari, and crab, or the Fritto Grandissimo, a crate filled with a selection of our fritto offerings (think: arancini al ragù, calamari, verdure and more). Indulge in Salumi e Formaggi Alla Grande! Choose from three different sizes of boards featuring our classic items. As you increase the size, discover more items and sought-after cuts and cheeses, accompanied by a variety of seasonal goods and fried delights.

PUNCH IT UP PÉT-NAT STYLE

Did you know that Prosecco has a new hippy cousin? Pét-Nat or “pétillant naturel” (naturally sparkling) is a natural wine with naturally forming light carbonation. Since pét-nats are natural wines, they tend to drink differently than conventionally produced wines. They can be more complex and interesting, often referred to as funky, savory, and even bright; these wines are perfect on a warm spring day. But we didn’t stop there – our experts will bring you Pét-Nat alla grande! Our new Pét-Nat Punch menu features a selection of six different spiked fruit punches made with seasonal fruit, herbs, and other flavors and finished tableside with a whole bottle of pét-nat.

SIT BACK AND RELAX ON MARIMEKKO

Il Patio di Eataly this season is dressed to impress by Marimekko, the Finnish lifestyle design house celebrated worldwide for its original prints and vibrant colors. Book your table now to lounge on custom-designed pillows featuring a variety of Marimekko prints that are sure to transport you to a spring oasis!

Ti aspettiamo!

​​Physicians who post COVID-19 vaccine misinformation may lose license, medical panel says 

The Federation of State Medical Boards warned July 29 that physicians and other healthcare professionals could be at risk of losing their medical licenses if they spread COVID-19 vaccine misinformation on social media, online and in the media.  

FSMB, a nonprofit that represents all U.S. state medical boards, said any clinicians who create or spread vaccine misinformation or disinformation risk disciplinary action by state medical boards, including suspension or revocation of their medical license, according to a statement emailed to Becker’s Hospital Review. 

“Due to their specialized knowledge and training, licensed physicians possess a high degree of public trust and therefore have a powerful platform in society, whether they recognize it or not,” FSMB said. “They also have an ethical and professional responsibility to practice medicine in the best interests of their patients and must share information that is factual, scientifically grounded and consensus-driven for the betterment of public health.” 

FSMB has not yet formally defined “misinformation” or “disinformation” in its policy, but the organization’s ethics committee is studying the issues of physician misinformation and disinformation and plans to provide more guidance at a later date, an FSMB spokesperson said in an emailed statement to Becker’s.  

“However, we currently view misinformation as sharing or distributing verifiably false information,” the spokesperson said. “We define disinformation as sharing or distributing information that the distributor knows is false.” 

While FSMB has not formed a recommendation yet for the definitions of misinformation and disinformation, state and territorial medical boards may use various terms, such as “professional misconduct” or “ethics violation,” in their own procedures to address concerns surrounding misinformation and disinformation, FSMB said.

In July, President Joe Biden called out social media platforms like Facebook for allowing vaccine misinformation to spread on its services, claiming that disinformation about the vaccines is “killing people,” according to CNBC. 

FSMB’s statement comes as the country grapples with an uptick in COVID-19 cases and hospitalizations. As of July 29, national cases are up 439.7 percent from the lowest average in June 2021, and just 49 percent of Americans are fully vaccinated, The New York Times reported.  

About 97 percent of hospitalized COVID-19 patients aren’t vaccinated, according to the report.

Editor’s note: This article was updated Aug. 5 at 4:45 p.m. CST to include additional statements from FSMB on the terms “misinformation” and “disinformation.”

Di Petsa Spring 2022 Ready-to-Wear Collection

Much of mainstream fashion wants what Dimitra Petsa has—just look at the many major designers cribbing her wet-look, Greek-goddess aesthetic. But if 2020’s lockdowns and fashion’s subsequent recalibration has taught us anything, it’s that emotion can’t be faked and a new generation of fashion lovers and customers are looking for a personal connection to their clothing. That’s why women like Gigi Hadid, Yseult, and Rina Sawayama are lining up for Petsa’s custom garments.

Her ready-to-wear, presented at Paris Fashion Week for the first time as a guest of the Fédération de la Haute Couture et de la Mode, contains the same level of passion and fury as her one-off gowns. The proof isn’t only in the sensitive way she drapes her jersey to cradle the bosom, slide down the hips, or pool on the ground around the wearer’s ankles—she describes her process both as “the body emerging from something” and as a method of “accentuating the naked body, not covering it up”—but in the many women from Greece and the U.K. who went to Paris to help make Petsa’s vision real.

Zooming together at around 11 p.m. in Paris, all the lights are on in a small French apartment and women are rushing about everywhere. Long-haired friends step in and out of the frame, torsos swaying and bums held taut in knit maxiskirts, gleefully modeling Petsa’s new collection. Others hold up cell-phone flashlights to further show off the minute craftsmanship of each piece, with seams tailored to gently swoop around a body’s curves. In the background another group is sitting on the floor, working away.

“I feel like a lot of designers, with Fashion Week coming back, have this idea of ‘let’s party,’” Petsa says. “But I still think a lot of people are apprehensive about touching each other again, about seeing each other again.” She’s called her collection Nostos-Touch; the touch part is obvious, representing the idea of wanting to be embraced but being wary of its consequences. Nostos is Greek for “homecoming,” sort of like Odysseus after a long journey through the Mediterranean.

Petsa is less concerned with the trials of that mythic man and more with the Sirens he finds along the way. She tapped into this darker side of femininity, the idea of mermaids caught in nets, of constraint and dangerous freedom, with a moody palette of cobalt, navy, burgundy, and gold. Even with its complicated drapery and cutouts, this collection is her most wearable offering yet, made from cotton jersey and Tencel and adorned with custom marine blue rings, bracelets, and necklaces.

At Paris Fashion Week, the Petsa Poseidonesses came together in a performance centered around the musician Lola Lolita. Models writhed, swayed, and lay down while Lolita commanded the ceremony. Petsa says she wants to move away from Western perceptions of Greek culture. Even those with a long memory and long scholarship of ancient cultures may be hard-pressed to remember the pre-Greeks, but many of those who do have hypothesized that the earliest cultures on the Peloponnesus were matriarchal. One hopes Petsa’s customers are willing to join her on this journey through time and womanhood—but if not, these are still some of the most beautiful sexy dresses and separates this season.

Acqua di Giò Profumo Giorgio Armani cologne

Here lies my first review…I wish I could say more. Honestly, I was expecting more from this cologne. It is highly rated and many people say it is a no-brainer, blind buy. I say: do NOT blind buy; you may be disappointed. Don’t get me wrong, this scent is good, but there is a time and a place for this guy instead of an all-arounder. If you can respect that, this cologne will suit you well. If not, you may want to take a rain check.

Without getting too much into the notes, let me rattle off the basics. In the opening you will notice a heavy blast of aquatic — almost salt-water — scent, with a hint of spice. The opening is what kills this fragrance from being more of a “fresh” fragrance due to the spice and opposing aquatic notes, in my opinion. The scent gets better as it matures, rounding into more of a spicy scent while keeping a slight aquatic note that is more bearable. Expect the scent to close with more of a spicy, smokey aroma, and that will be game.

Sillage is above average as far as performance, and while I don’t feel the projection is amazing, I have heard mixed comments. Compliment-wise…it lacks. I have tried this in different settings such as bars, coffee shops, office areas, and shopping trips. I have had most success in the office areas as far as compliments, but it is not the compliment monster that many hold it up to be.

Ultimately, where do I feel it is best served? I feel it is aimed more towards an evening with your office team or a date, but in my opinion I do not feel it would hold in a club which is a targeted hotspot for this cologne, as there are many other colognes that will out perform ADG. Though, while I do believe it is more of an evening fragrance, I feel it may work in an office with the right man who holds high confidence in himself.

Overall, if you are a younger man starting at a prodigious college, a man who is in an environment where wallets are a bit more padded than usual, or a man going out for a romantic date, then I say this spciy-fresh cologne will suit you nicely. If you are simply looking for another cologne to add to your collection that you wish to wear all the time throughout the day, then there are better options out there for you, and I highly recommend sampling before purchasing.

Age type: Mature, refined
Occasion: Evening, night-out, select office
Season: Summer, Spring

Scent: 7 out of 10
Performance: 9 out of 10
Projection: 8 out of 10
Versatility: 5 out of 10
Compliments: 7 out of 10
Overall: 7 out of 10

Blind buy worthy: No
Final remarks: There are better out there that are more versatile and have that “wow” factor. Do yourself a favor and test this fragrance out; this hyped fragrance will either be a god-send or a mistake depending on the person.

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90,000 For Whom the Bell Tolls: Delta Strain, Vaccination and Cancer Patients

Oncology news

09/08/2021

For Whom the Bell Tolls: Delta Strain, Vaccination and Cancer Patients

Sheiko Andrey Vladimirovich
Radiotherapist, Head of
radiotherapy department No. 2 OKOD,
Vladimir

The delta strain (B1.617.2) of coronavirus infection, first reported in India in December 2020, had already become the most common SARS-CoV-2 strain in the country by mid-April 2021, and by May 19, 2021 it had spread to 43 states on six continents.At present, the share of the delta strain in the structure of coronavirus variants in the world is approaching 100%, almost completely displacing the alpha strain (Fig. 1, 2) [1].

Figure 1 . The percentage of COVID-19 strains is 90,290 among cases of the disease by the end of July – beginning of August 2021.

Figure 2 . The incidence of the delta strain COVID-19
from March to July 2021.

The delta strain of coronavirus has mutations T19R, Δ157-158, L452R, T478K, D614G, P681R and D950N in the spike protein, which leads to more intense replication, high viral load and high infectiousness of the pathogen.Until now, there has been no data on the effectiveness of vaccines against COVID-19 caused by the new Indian strain.

At the end of July 2021, the journal NEJM published the results of a test-negative retrospective case-control study evaluating the effectiveness of vaccination against symptomatic coronavirus infection caused by delta- and alpha-strains of SARS-CoV-2 during the period of the beginning of circulation in the delta- strain [2]. The British study included vaccinated patients over 16 years of age with positive and negative (for test-negative case-control analysis) results of PCR tests for COVID-19, obtained no later than ten days from the onset of symptoms of the disease in the period from October 2020 to May. 2021 year.Depending on the vaccination status, the patients were divided into three groups:

1. persons with symptoms of the disease that appeared within 21 days or more from the time of the first dose of vaccine to the eve of the second dose;
2. persons with symptoms of the disease that appeared within 14 days or more from the moment of the second dose of the vaccine;

90,005 persons with symptoms of illness onset within 21 days or more after the first dose of vaccine, including any period after the second dose.

Genome-wide sequencing was performed in all cases to determine the strain of the virus. Of the 38,592 cases, 19,109 vaccinated patients with symptomatic COVID-19 caused by alpha (14,837 cases) and delta (4,272 cases) strains were recruited into the study. Logistic regression analysis was used to assess the likelihood of symptomatic PCR-confirmed COVID-19 infection among vaccinated versus unvaccinated (control group). The results of evaluating the effectiveness are presented in Figure 3.

Figure 3 . Vaccination efficacy against alpha and delta strains
, depending on the dose and type of vaccines.

In a British study, it can be seen that the effectiveness of two vaccines, BNT162b2 and ChAdOx1 nCoV-19, was evaluated. But, in addition, an analysis of the effectiveness of the so-called “any vaccine” group was carried out, which included all persons vaccinated with other vaccines that did not belong to the two above.This patient cohort is of particular interest. Vaccination efficacy in the “any vaccine” group among those infected with the delta strain was noticeably lower after the first dose of vaccines (30.7%; 95% confidence interval [CI] 25.2-35.7) than in those with alpha -strain (48.7%; 95% CI 45.5-51.7). However, this difference in efficacy was almost leveled after the second dose: 87.5% (95% CI 85.1-89.5) for the alpha strain and 79. 6% (95% CI 76.7-82.1) for the delta strain.

Thus, according to the results of the study, any of the vaccines was effective against the delta strain SARS-CoV-2, however, the maximum effect can be achieved only if two doses are administered (79.6% with 95% CI 76.7-82, 1 in the “any vaccine” group).The result is very encouraging and inspiring a certain amount of optimism. Naturally, it should be remembered that a test-negative case-control study has certain drawbacks (cases of misinterpretation of false-negative tests, since both sick and control participants have symptoms similar to COVID-19; distortion from common predictors of vaccination and the risk of exposure to infection, such as belonging to a priority group by age or occupation, etc.etc.). However, in accordance with the WHO recommendations in 2021, this method remains the most effective and contains the least amount of errors in assessing the effectiveness of vaccination against COVID-19 [3].

Against this positive background, the situation with the rate of vaccination in the Russian Federation looks increasingly depressing (only 18% of the population was fully vaccinated against SARS-CoV-2 as of early August 2021) (Fig. 4).

Figure 4 . The rate of vaccination in the world at the beginning of August 2021.

An unusual and highly interesting study was published in the journal Nature Medicine in July 2021 assessing both the popularity and rejection of vaccination in middle and low income countries [4]. The study included 10 countries in Asia, Africa, South America, as well as the United States and Russia. According to the survey results of 44,260 respondents, the average willingness to be vaccinated in the studied countries was 80.3% (95% CI 74.9-85.6). In Russia, the willingness to be vaccinated among the population was only 30.4% (95% CI 29.1-31.7).The main reasons for rejection of vaccination were the fear of pronounced side effects, the belief in the lack of effectiveness of vaccination and adherence to conspiracy theories (!) (Fig. 5).

Figure 5 . Reasons for not being vaccinated in various middle- and low-income countries [4].

An even more ambiguous and alarming situation arises with the vaccination of cancer patients at extremely high risk of developing severe symptomatic forms of COVID-19 and death a multitude of unmeasurable distorting factors [5].

However, one cannot but recognize the positive effect of the Temporary Methodological Recommendations on the procedure for vaccination against COVID-19 of the Ministry of Health of the Russian Federation, released in July 2021, this time very convincingly regulating the procedure for immunizing cancer patients [6]. Particular attention is paid to this vaccine Gam-COVID-Vac (Sputnik V) as the most researched. The use of the Sputnik V vaccine without additional restrictions is now recommended for all cancer patients who have completed antitumor treatment, regardless of the stage and form of the disease, as well as patients in the course of cyclic treatment without signs of hematological toxicity and patients who are candidates for surgical treatment no later than 14 days before the date of surgery. It is recommended to consider vaccination with Sputnik V in patients in the course of anticancer treatment with anticipated hematological toxicity during the period of minimal risk of its development (no later than two weeks before the start of chemotherapy, radiation therapy, chemoradiation therapy, or in the intervals between courses or at the end of them). Vaccinations are also subject to oncohematological patients before or during treatment with an achieved lymphocyte level of more than 1.0 × 10 ³ cells / μl and B cells more than 50 / μl, as well as patients receiving immunotherapy without signs of hematological toxicity.Convincing data on the possibility and relative safety of the use of vaccines “EpiVacCorona”, “CoviVac” and “Sputnik Light” in cancer patients have not yet been presented.

It is undeniable that cancer patients are the highest priority group in the vaccination schedule. However, the use of vaccines in this category of patients should always take into account the toxicity of the treatment, the types and methods of chemotherapy, immunotherapy, hormone therapy or biotherapy, the timing of treatment, the patient’s condition and the prognosis of his disease.

So, the British study made a powerful new argument in the undeniable benefit of vaccination against COVID-19, caused not only by the already studied strains of SARS-CoV-2, but also by the delta strain that is currently raging in all countries of the world. It is highly expected that the maximum effectiveness of immunization against the delta variant reaches only after the introduction of the second vaccine. The updated Methodological Recommendations of the Ministry of Health, released in July 2021, finally directed the vector of immunization towards cancer patients, whose vaccination has the highest priority.Obviously, vaccination will not deprive us and our patients of the risk of primary or re-infection with coronavirus infection, but it will definitely get rid of a severe symptomatic course and high risks of complications and death. But only a full-fledged maximum coverage of the population with immunization can even not defeat COVID-19, but at least curb the pandemic.

Sources:

1. ourworldindata.org.
2. Lopez Bernal J, Andrews N, Gower C, et al.Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant. N Engl J Med. 2021 Jul 21; NEJMoa2108891. doi: 10.1056 / NEJMoa2108891. Epub ahead of print. PMID: 34289274. PMCID: PMC8314739.
3. Evaluation of the effectiveness of the vaccine against COVID-19: WHO interim guidance dated 17.03.2021.
4. Solís Arce JS, Warren SS, Meriggi NF, et al. COVID-19 Vaccine Acceptance and Hesitancy in Low- and Middle-income Countries. Nat Med. 2021 doi.org/10.1038/s41591-021-01454-y.
5. Polyakov A.A., Lunin V.V., Abbaisbeyli F.M. and others. Vaccination against SARS-COV-2 in oncological practice. Oncohematology. 2021; 16 (2): 70-80. DOI: 10.17650 / 1818-8346-2021-16-2-70-80.
6. Temporary guidelines “Procedure for vaccination of the adult population against COVID-19” dated 07.24.2021 of the Ministry of Health of the Russian Federation and the Federal State Budgetary Institution “NMITs TPM” of the Ministry of Health of the Russian Federation.